Investigasi resistensi Anopheles sp. terhadap insektisida piretroid dan kemungkinan terjadinya mutasi gen voltage gated sodium channel (VGSC)
نویسندگان
چکیده
منابع مشابه
A prokaryotic voltage-gated sodium channel.
The pore-forming subunits of canonical voltage-gated sodium and calcium channels are encoded by four repeated domains of six-transmembrane (6TM) segments. We expressed and characterized a bacterial ion channel (NaChBac) from Bacillus halodurans that is encoded by one 6TM segment. The sequence, especially in the pore region, is similar to that of voltage-gated calcium channels. The expressed cha...
متن کاملMulti-country Survey Revealed Prevalent and Novel F1534S Mutation in Voltage-Gated Sodium Channel (VGSC) Gene in Aedes albopictus
BACKGROUND Aedes albopictus is an important dengue vector because of its aggressive biting behavior and rapid spread out of its native home range in Southeast Asia. Pyrethroids are widely used for adult mosquito control, and resistance to pyrethroids should be carefully monitored because vector control is the only effective method currently available to prevent dengue transmission. The voltage-...
متن کاملThe hitchhiker’s guide to the voltage-gated sodium channel galaxy
Eukaryotic voltage-gated sodium (Nav) channels contribute to the rising phase of action potentials and served as an early muse for biophysicists laying the foundation for our current understanding of electrical signaling. Given their central role in electrical excitability, it is not surprising that (a) inherited mutations in genes encoding for Nav channels and their accessory subunits have bee...
متن کاملVoltage-gated ion channel accessory subunits: sodium, potassium, or both?
Commentary The voltage-gated potassium channel subunit Kv4.2 is a pore-forming alpha subunit of A-type potassium channels. Kv4.2, encoded by the KCND2 gene, is broadly expressed in the central nervous system and is predominantly localized on neuronal dendrites, with increased density on distal dendrites (1). A-type potassium channels are important regulators of neuronal excitability, modulating...
متن کاملVoltage-gated sodium channel expression in rat spiral ganglion neurons.
The spiral ganglion neurons (SGN) provide the afferent innervation of the hair cells in the organ of Corti and relay auditory information from the inner ear to the brain. Voltage-gated sodium channels (Na(V)) initiate and propagate action potentials that encode this sensory information but little is known regarding the subtypes expressed in these cells. We have used RT-PCR and immunohistochemis...
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ژورنال
عنوان ژورنال: Jurnal Entomologi Indonesia
سال: 2019
ISSN: 2089-0257,1829-7722
DOI: 10.5994/jei.15.3.134